Odame, F.;Hosten, Eric C.;Betz, R.;Krause, J.;Frost, Carminita L.;Lobb, K.;Tshentu, Zenixole R. published 《Synthesis, characterization, computational studies and DPPH scavenging activity of some triazatetracyclic derivatives》 in 2021. The article was appeared in 《Journal of the Iranian Chemical Society》. They have made some progress in their research.SDS of cas: 5805-39-0 The article mentions the following:
Some dihydrobenzo[4,5]imidazo[1,2-c]quinazolines I (R = Me, 2-methylpropyl, Ph, etc.; R1 = H, Me) have been synthesized from aldehydes RCHO and ketones RC(O)CH3, using the ketones as both reagents and solvents and THF (THF) as the solvent for the aldehydes, to yield the triazatetracyclics I. The compounds I have been characterized with spectroscopy and microanal. The crystal structures of triazatetracyclics I [R = Me, R1 = Me (II); R = Et, R1 = Me (III); and R = Ph, R1 = H (IV)] have been discussed. The computed NMR, IR, mol. electrostatic potential and frontier MOs of compounds II, III and IV have been discussed. The M06 functional gave most of its values closest to the exptl. values for the bond lengths and bond angles of compounds II and III. For compound IV, none of the functionals gave values for bond lengths and bond angles that were consistent with the exptl. values, but M06 gave values closest to exptl. values. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity of the triazatetracyclics showed that compound II exhibits significant DPPH scavenging activity with an IC50 of 56.18μM compared to 2.37μM for ascorbic acid. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem