Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline《An efficient green synthesis of 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones catalyzed by iodine in ionic liquids》 was published in 2017. The authors were Zhang, Mei-Mei;Wang, Yue;Liu, Jian-Quan;Wang, Xiang-Shan, and the article was included in《Heterocyclic Communications》. The author mentioned the following in the article:
Benzene-1,2-diamine was treated with 2-nitrobenzaldehyde in EtOH, and the product was reduced with hydrazine hydrate in the presence of Fe(C) without separation to give 2-(1H-benzo[d]imidazol-2-yl)aniline. Reactions of compound 2-(1H-benzo[d]imidazol-2-yl)aniline with isatins in the presence of iodine in an ionic liquid furnished 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones I [R= H, 5′-Me, 4′-Cl, 6′-Br, 7′-F, etc.] in high yields.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem