Product Details of 5805-39-0《Microwave Assisted Green Synthesis of Benzimidazole Derivatives and Evaluation of Their Anticonvulsant Activity》 was published in 2019. The authors were Sahoo, Biswa Mohan;Banik, Bimal Krishna;Mazaharunnisa;Rao, Naidu Srinivasa;Raju, Bodapati, and the article was included in《Current Microwave Chemistry》. The author mentioned the following in the article:
N-(Benzimidazolylphenyl)cinnamides I (R = Ph, 2-ClC6H4, 4-ClC6H4, 4-FC6H4, 4-HC6H4) are synthesized by reaction between ortho-phenylene diamine and anthranilic acid followed by acetylation in the presence of acetic anhydride and Claisen-Schmidt condensation with substituted benzaldehydes RCHO. Both conventional and microwave irradiation technol. are followed to get the titled compounds I. The titled compounds are screened for their anticonvulsant activity and neurotoxicity. By the help of microwave synthesis, the yield of product was increased in less reaction time. So, it follows Green chem. approach by making above reactions eco-friendly. Some of the compounds exhibited significant anticonvulsant activity as compared to standard drug. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem