The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.Quality Control of Tricyclohexylphosphonium tetrafluoroborate. The article 《Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:3724-19-4).
One-bead one-compound combinatorial chem. together with a high-throughput screen based on fluorescently labeled enzyme allowed the identification of slow binding inhibitors of human serine racemase (hSR). A peptide library of topog. segregated encoded resin beads was synthesized, and several hSR-binding compounds were isolated, identified, and resynthesized for further kinetic study. Of these, several showed inhibitory effects with moderate potency (high micromolar KIs) toward hSR. A clear structural motif was identified consisting of 3-phenylpropionic acid and histidine moieties. Importantly, the inhibitors identified showed no structural similarities to the natural substrate, L-serine. Detailed kinetic analyses of the properties of selected inhibitors show that the screening protocol used here selectively identifies slow binding inhibitors. They provide a pharmacophore for the future isolation of more potent ligands that may prove useful in probing and understanding the biol. role of hSR.
《Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)Safety of 3-Pyridinepropionic acid.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem