Application In Synthesis of Pentaerythrityltetrabromide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about A New, Second Generation Trithiol Bifunctional Chelate for 72,77As: Trithiol(b)-(Ser)2-RM2. Author is Najafi Khosroshahi, Firouzeh; Feng, Yutian; Ma, Li; Manring, Simon; Rold, Tammy L.; Gallazzi, Fabio A.; Kelley, Steven P.; Embree, Mary F.; Hennkens, Heather M.; Hoffman, Timothy J.; Jurisson, Silvia S..
Trithiol chelates are suitable for labeling radioarsenic (72As: 2.49 MeV β+, 26 h; 77As: 0.683 MeV β-, 38.8 h) to form potential theranostic radiopharmaceuticals for positron emission tomog. (PET) imaging and therapy. A trithiol(b)-(Ser)2-RM2 bioconjugate and its arsenic complex were synthesized and characterized. The trithiol(b)-(Ser)2-RM2 bioconjugate was radiolabeled with no-carrier-added 77As in over 95% radiochem. yield and was stable for over 48 h, and in vitro IC50 cell binding studies of [77As]As-trithiol(b)-(Ser)2-RM2 in PC-3 cells demonstrated high affinity for the gastrin-releasing peptide (GRP) receptor (low nanomolar range). Limited biodistribution studies in normal mice were performed with HPLC purified 77As-trithiol(b)-(Ser)2-RM2 demonstrating both pancreatic uptake and hepatobiliary clearance.
This compound(Pentaerythrityltetrabromide)Application In Synthesis of Pentaerythrityltetrabromide was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem