Category: imidazoles-derivatives. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Redispersion of cryoaggregated gold nanoparticle by means of laser irradiation and effect on biological interactions. Author is Mishra, Ankita; Shaikh, Shazia; Kumar, Ashok.
Agglomeration/aggregation is an indispensable phenomenon observed by different nanoparticles. In the present study, com. grade (50 nm) and chem. synthesized (40 nm) gold nanoparticles (AuNPs) were aggregated at sub-zero temperatures, followed by disruption of the AuNP aggregates via nanosecond laser-ablation and subsequent effect on biol. interactions. AuNPs were characterized pre/post laser-ablation via UV-visible spectroscopy, transmission electron microscopy, at. force microscopy, etc. The process of freezing (aggregation) and laser-ablation (dispersion) was performed multiple times, in order to compare the yield of nanoparticles after each cycle of laser-ablation. Further, AuNPs pre/post laser-ablation were assessed for cytotoxicity, protein-corona formation, and cell-uptake by in vitro studies using RAW264.7, Caco-2 and Neuro-2 a cell lines. Aggregates for both the types of AuNPs displayed fragmentation following first cycle of laser-ablation. In addition, AuNPs obtained after fragmentation of the aggregates showed reduction in diameter and reshaping, as compared to native AuNPs. The size and shape of the nanoparticles after second and third cycle of laser-ablation was same as that obtained after first cycle of ablation. Both laser-ablated and native AuNPs showed similar effects on viability of RAW 264.7 and Caco-2 cells, after 24 h and 48 h of exposure. Cell uptake of native and laser-ablated AuNPs was observed to be a size dependent phenomenon. Present findings showed that nanosecond laser ablation of cryoaggregated AuNPs lead to changes in the phys. properties of AuNPs post ablation like size and shape, however, biol. interaction with cells remained same. This work is first report on biol. interactions of AuNPs generated via laser-ablation of cryoaggregated AuNPs.
《Redispersion of cryoaggregated gold nanoparticle by means of laser irradiation and effect on biological interactions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Hydrogen tetrachloroaurate(III) trihydrate)Category: imidazoles-derivatives.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem