Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Current Organic Synthesis called Comparison of Conventional and Microwave Synthesis of Phenyl-1H-pyrazoles and Phenyl-1H-pyrazoles-4-carboxylic Acid Derivatives, Author is Machado, Antonio S.; de Carvalho, Flavio S.; Mouraa, Rayssa B. P.; Chaves, Lorrayne S.; Liao, Luciano M.; Sanz, German; Vaz, Boniek G.; Rodrigues, Marcella F.; Romao, Wanderson; Menegatti, Ricardo; Silva, Gloria N. S., which mentions a compound: 87488-84-4, SMILESS is BrC1=CC=CC=C1N2N=CC=C2, Molecular C9H7BrN2, Application of 87488-84-4.
The purpose of this study was the optimization of the conventional synthesis of the pyrazole rings I (R1 = H) and the oxidation of phenyl-1H-pyrazole-4-carbaldehydes I (R = H, 2-Cl, 3-Br, 4-CF3, etc.; R1 = CHO) to phenyl-1H-pyrazole-4-carboxylic acids I (R1 = COOH) through Microwave- Assisted Organic Synthesis (MAOS). A comparison between conventional synthesis and conventional synthesis with microwave heating using the synthesis method of pyrazole ring described by Finar and Godfrey and for the oxidation of phenyl-1H-pyrazole-4-carbaldehyde, and the method described by Shriner and Kleiderer was used. MAOS reduces the reaction time to obtain all compounds compared to conventional heating. At a temperature of 60°C, 5 min of reaction time, and power of 50 W, the yield of phenyl-1H-pyrazoles I (R1 = H) was in the range of 91 – 98% using MAOS, which is better than conventional heating (72 – 90%, 75°C, 2 h). An improvement in the yield for the oxidation reaction was also achieved with MAOS. The compounds I (R1 = COOH) were obtained with yields ranging from 62 – 92% (80°C, 2 min, 150 W), while the yields with conventional heating were in the range of 48 – 85% (80°C, 1 h). The 26 compounds I were achieved through an easy work-up procedure with no chromatog. separation
《Comparison of Conventional and Microwave Synthesis of Phenyl-1H-pyrazoles and Phenyl-1H-pyrazoles-4-carboxylic Acid Derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(2-Bromophenyl)-1H-pyrazole)Application of 87488-84-4.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem