Quality Control of Tricyclohexylphosphonium tetrafluoroborate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543. Author is Fitzgerald, Monica A.; Soltani, Omid; Wei, Carolyn; Skliar, Dimitri; Zheng, Bin; Li, Jun; Albrecht, Jacob; Schmidt, Michael; Mahoney, Michelle; Fox, Richard J.; Tran, Kristy; Zhu, Keming; Eastgate, Martin D..
BMS-911543 (I) is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development of a short and efficient synthesis of this mol. is described. During the course of our studies, a Ni-mediated C-N bond formation was invented, which enabled the rapid construction of the highly substituted 2-aminopyridine core. The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only eight steps starting from readily available materials.
《Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Tricyclohexylphosphonium tetrafluoroborate)Quality Control of Tricyclohexylphosphonium tetrafluoroborate.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem