So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Trost, Barry M.; Jiao, Zhiwei; Liu, Ying; Min, Chang; Hung, Chao-I. Joey researched the compound: tert-Butyl 2-cyanoacetate( cas:1116-98-9 ).Name: tert-Butyl 2-cyanoacetate.They published the article 《Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes》 about this compound( cas:1116-98-9 ) in Journal of the American Chemical Society. Keywords: palladium catalyzed enantioselective cycloaddition aliphatic dipole; chiral cyclohexne spiro heptane synthesis. We’ll tell you more about this compound (cas:1116-98-9).
Design and exploration of new intermediates for chemo-, regio-, and stereoselective cycloadditions remain a formidable challenge in modern organic synthesis. Compared to the well-developed 1,3-dipolar cycloadditions, Pd-catalyzed 1,4-dipolar cycloadditions are generally limited to specialized substrates due to the inherent nature of the thermodynamically driven intramol. transformations and undesired isomerizations. Herein, we demonstrate the use of ligated palladium catalysts to control and modulate the intermol. reactivity of aliphatic 1,4-dipoles, enabling two distinctive cycloaddition pathways with a broad scope of acceptors. This atom-economic process also features an eco-friendly in situ deprotonation strategy to generate the corresponding active palladium-mediated dipoles. Overall, a diverse array of chiral 6-membered rings and spiro [2.4] heptanes were prepared in high yield and selectivity. In addition, an unexpected property of cyano-stabilized carbanions was discovered and investigated, which can be useful in designing and predicting future transformations.
The article 《Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes》 also mentions many details about this compound(1116-98-9)Name: tert-Butyl 2-cyanoacetate, you can pay attention to it, because details determine success or failure
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem