Why do aromatic interactions matter of compound: 3724-19-4

Although many compounds look similar to this compound(3724-19-4)Application In Synthesis of 3-Pyridinepropionic acid, numerous studies have shown that this compound(SMILES:OC(=O)CCC1=CC=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Science (Washington, DC, United States) called A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents, Author is Qin, Tian; Cornella, Josep; Li, Chao; Malins, Lara R.; Edwards, Jacob T.; Kawamura, Shuhei; Maxwell, Brad D.; Eastgate, Martin D.; Baran, Phil S., which mentions a compound: 3724-19-4, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2, Application In Synthesis of 3-Pyridinepropionic acid.

N-Hydroxytetrachlorophthalimide esters of carboxylic acids such as I (Ts = 4-MeC6H4SO2) underwent chemoselective coupling reactions with alkylzinc reagents such as R2Zn [R = Me, [13C]Me, Et, Bu, Me(CH2)8, H2C:CH(CH2)n, cyclohexylmethyl, Ph(CH2)5, MeCCCH2CH2, Me3SiCC(CH2)3, Cl(CH2)4, PhCH2O(CH2)3, TBDMSO(CH2)3, 2-(1,3-dioxan-2-yl)ethyl] (purchased or generated in situ) in the presence of NiCl2(MeOCH2CH2OMe) [NiCl2(glyme)] to yield decarboxylated coupling products such as II [R = Me, [13C]Me, Et, Bu, Me(CH2)8, H2C:CH(CH2)n, cyclohexylmethyl, Ph(CH2)5, MeCCCH2CH2, Me3SiCC(CH2)3, Cl(CH2)4, PhCH2O(CH2)3, TBDMSO(CH2)3, 2-(1,3-dioxan-2-yl)ethyl], allowing activated alkylcarboxylic acids to be used chemoselectively in coupling reactions instead of their parent alkyl derivatives The method was also used in conjunction with solid-phase peptide synthesis to yield peptides with novel side chains through activation of aspartate, glutamate, and proline γ-amides of glutamate residues. N-Hydroxyphthalimide esters of tertiary alkyl carboxylic acids such as pivalic acid underwent conjunctive coupling and decarboxylation reactions with the activated Knochel zinc reagent PhZnCl·LiCl (generated in situ from PhBr) and benzyl acrylate in the presence of NiCl2(glyme) to give benzyl α-phenyl-β-tert-alkyl carboxylates such as t-BuCH2CHPhCO2CH2Ph.

Although many compounds look similar to this compound(3724-19-4)Application In Synthesis of 3-Pyridinepropionic acid, numerous studies have shown that this compound(SMILES:OC(=O)CCC1=CC=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem