Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B. published an article about the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3,SMILESS:ClC1=C(C=C(CBr)C=C1)F ).Recommanded Product: 206362-80-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:206362-80-3) through the article.
Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of I, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, I was selected for further preclin. evaluation.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem