Dressman, Bruce A.; Tromiczak, Eric G.; Chappell, Mark D.; Tripp, Allie E.; Quimby, Steven J.; Vetman, Tatiana; Fivush, Adam M.; Matt, James; Jaramillo, Carlos; Li, Renhua; Khilevich, Albert; Blanco, Maria-Jesus; Smith, Stephon C.; Carpintero, Mercedes; de Diego, Jose Eugenio; Barberis, Mario; Garcia-Cerrada, Susana; Soriano, Jose F.; Schkeryantz, Jeffrey M.; Witkin, Jeffrey M.; Wafford, Keith A.; Seidel, Wesley; Britton, Thomas; Overshiner, Carl D.; Li, Xia; Wang, Xu-Shan; Heinz, Beverly A.; Catlow, John T.; Swanson, Steven; Bedwell, David; Ornstein, Paul L.; Mitch, Charles H. published an article about the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3,SMILESS:ClC1=C(C=C(CBr)C=C1)F ).Synthetic Route of C7H5BrClF. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:206362-80-3) through the article.
Neg. modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to prepare and optimize a series of conformationally constrained 3,4-disubstituted bicyclo[3.1.0]hexane glutamic acid analogs as orthosteric (glutamate site) mGlu2/3 receptor antagonists. This work led to the discovery of a highly potent and efficacious tool compound I (hmGlu2 IC50 46 ± 14.2 nM, hmGlu3 IC50 = 46.1 ± 36.2 nM). Compound I showed activity in the mouse forced swim test with a minimal ED (MED) of 1 mg/kg i.p. While in rat EEG studies it exhibited wake promoting effects at 3 and 10 mg/kg i.p. without any significant effects on locomotor activity. Compound I thus represents a novel tool mol. for studying the impact of blocking mGlu2/3 receptors both in vitro and in vivo.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem