COA of Formula: C7H11NO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging. Author is Zhang, Jingming; Rakhimbekova, Anastasia; Duan, Xiaojiang; Yin, Qingqing; Foss, Catherine A.; Fan, Yan; Xu, Yangyang; Li, Xuesong; Cai, Xuekang; Kutil, Zsofia; Wang, Pengyuan; Yang, Zhi; Zhang, Ning; Pomper, Martin G.; Wang, Yiguang; Barinka, Cyril; Yang, Xing.
Surgery is an efficient way to treat localized prostate cancer (PCa), however, it is challenging to demarcate rapidly and accurately the tumor boundary intraoperatively, as existing tumor detection methods are seldom performed in real-time. To overcome those limitations, we develop a fluorescent mol. rotor that specifically targets the prostate-specific membrane antigen (PSMA), an established marker for PCa. The probes have picomolar affinity (IC50 = 63-118 pM) for PSMA and generate virtually instantaneous onset of robust fluorescent signal proportional to the concentration of the PSMA-probe complex. In vitro and ex vivo experiments using PCa cell lines and clin. samples, resp., indicate the utility of the probe for biomedical applications, including real-time monitoring of endocytosis and tumor staging. Experiments performed in a PCa xenograft model reveal suitability of the probe for imaging applications in vivo.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem