Name: tert-Butyl 2-cyanoacetate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N’-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy. Author is Chen, Zhipeng; Zhang, Lina; Yang, Junjie; Zheng, Lu; Hu, Fanjie; Duan, Siqin; Nandakumar, Kutty Selva; Liu, Shuwen; Yin, Hang; Cheng, Kui.
Herein, the chem. optimization of initial hit, 1-phenyl-3-(thiophen-2-yl)urea, which resulted in the identification of SMU-C80 I (V) (EC50 = 31.02 ± 1.01 nM) as a TLR2-specific agonist with a 370-fold improvement in bioactivity was presented. Mechanistic studies revealed that SMU-C80 (V), through TLR1/2, recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1βfrom human, but not murine, cells. To the best of the knowledge, it is the first species-specific TLR1/2 agonist reported until now. Moreover, SMU-C80 (V) increased the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro. In summary, a highly efficient and specific human TLR1/2 agonist II (R1 = H, Et, iso-Pr, phenylethyl, etc.; R2 = 4-fluorophenyl, naphth-1-yl, 4-bromonaphth-1-yl, etc.; n = 1-3; Y = O, S), III (R3 = H, phenyl) and IV (X = CH, N) that acts through the MyD88 and NF-κB pathway, facilitating cytokine release and the simultaneous activation of immune cells that in turn affects the apoptosis of cancer cells was obtained.
In addition to the literature in the link below, there is a lot of literature about this compound(tert-Butyl 2-cyanoacetate)Name: tert-Butyl 2-cyanoacetate, illustrating the importance and wide applicability of this compound(1116-98-9).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem