Guo, Zhi-Hua; Yin, Yong; Wang, Cong; Wang, Peng-Fei; Zhang, Xing-Tao; Wang, Zhong-Chang; Zhu, Hai-Liang published the article 《Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents》. Keywords: preparation salicylic acid metronidazole antibacterial; crystal structure; Antibacterial activity; Molecular docking; S. aureus TyrRS; Salicylic acid derivatives.They researched the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3 ).Formula: C7H5BrClF. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:206362-80-3) here.
A series of novel salicylic acid derivatives containing metronidazole as Staphylococcus aureus Tyrosyl-tRNA synthetase (TyrRS) inhibitors have been synthesized and evaluated their biol. activities as potential antibacterial agents. Among these compounds, compound I exhibited the most potent antibacterial activity against Gram-pos. (S. aureus ATCC 6538 and Bacillus subtilis ATCC 6633) and Gram-neg. (Escherichia coli ATCC 35218 and Pseudomonas aeruginosa ATCC 13525) with MICs of 0.39-1.57 μg/mL and showed the most potent S. aureus Tyrosyl-tRNA synthetase inhibitory with 2.3 μM. Docking simulation was performed to insert compound I into the crystal structure of S. aureus Tyrosyl-tRNA synthetase active site to determine the probable binding model. These results suggested that compound I may be a promising antibacterial agent.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Bromomethyl)-1-chloro-2-fluorobenzene)Formula: C7H5BrClF, illustrating the importance and wide applicability of this compound(206362-80-3).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem