In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro, published in 2017-01-29, which mentions a compound: 206362-80-3, Name is 4-(Bromomethyl)-1-chloro-2-fluorobenzene, Molecular C7H5BrClF, Application of 206362-80-3.
Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here we developed a potent “”hit”” compound, VSP-51, which is a novel selective PPARγ-modulating ligand with improved therapeutic profiles in vitro compared to the multi-billion dollar TZD drug rosiglitazone (Rosi). Unlike Rosi, VSP-51 is a partial agonist of PPARγ with improved insulin sensitivity due to its ability to bind PPARγ with high affinity without stimulating adipocyte differentiation and the expression of adipogenesis-related genes. We have determined the crystal structure of the PPARγ ligand-binding domain (LBD) in complex with VSP-51, which revealed a unique mode of binding for VSP-51 and provides the mol. basis for the discrimination between VSP-51 from TZDs and other ligands such as telmisartan, SR1663 and SR1664. Taken together, our findings demonstrate that: a. VSP-51 can serve as a promising candidate for anti-diabetic drug discovery; and b. provide a rational basis for the development of future pharmacol. agents targeting PPARγ with advantages over current TZD drugs.
In some applications, this compound(206362-80-3)Application of 206362-80-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem