Application of 58656-04-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Synthesis of Lapatinib via direct regioselective arylation of furfural. Author is Erickson, Greg; Guo, Jiasheng; McClure, Mike; Mitchell, Mark; Salaun, Marie-Catherine; Whitehead, Andrew.
A new synthesis of Lapatinib I, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.
In addition to the literature in the link below, there is a lot of literature about this compound(Tricyclohexylphosphonium tetrafluoroborate)Application of 58656-04-5, illustrating the importance and wide applicability of this compound(58656-04-5).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem