Marhadour, Sophie; Marchand, Pascal; Pagniez, Fabrice; Bazin, Marc-Antoine; Picot, Carine; Lozach, Olivier; Ruchaud, Sandrine; Antoine, Maud; Meijer, Laurent; Rachidi, Najma; Le Pape, Patrice published the article 《Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents》. Keywords: diarylimidazopyridine preparation antileishmanial; aryl boronic acid Suzuki reaction aryl halide arylation.They researched the compound: Tricyclohexylphosphonium tetrafluoroborate( cas:58656-04-5 ).Recommanded Product: 58656-04-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:58656-04-5) here.
A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds I(R = MeO, EtO2C-) and II, the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem