Safety of 3-Pyridinepropionic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Protease-catalyzed resolutions using the 3-(3-pyridine)propionyl anchor group: p-toluenesulfonamide. Author is Savile, Christopher K.; Kazlauskas, Romas J..
The procedure for resolution of N-3-(3-pyridine)propionyl-p-tolylsulfinamide is presented. The 3-(3-pyridine)propionyl group mimics phenylalanine and increases substrate binding and solubility in water, thereby increasing the rates of protease-catalyzed reactions. In addition, the 3-(3-pyridine)propionyl group eliminates chromatog., since mild acid extraction separates the remaining starting material and product. To demonstrate the synthetic usefulness of this strategy, multi-gram quantities of (R)- and (S)-p-toluenesulfinamide with α-chymotrypsin were resolved.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem