In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Pentanidium-catalyzed direct assembly of vicinal all-carbon quaternary stereocenters through C(sp3)-C(sp3) bond formation, published in 2021, which mentions a compound: 1116-98-9, mainly applied to vicinal all carbon quaternary stereocenter compound preparation enantioselective diastereoselective; racemic tertiary bromide secondary carbanion substitution reaction pentanidium catalyst, SDS of cas: 1116-98-9.
The stereoselective construction of vicinal all-carbon quaternary stereocenters has long been a formidable synthetic challenge. Direct asym. coupling of a tertiary carbon nucleophile with a tertiary carbon electrophile is the most straightforward approach, but it is sterically and energetically disfavored. Herein, a catalytic asym. substitution, where racemic tertiary bromides coupled directly with racemic secondary or tertiary carbanion, creating a series of congested C(sp3)-C(sp3) bonds, including isolated all-carbon quaternary stereocenters, vicinal tertiary/all-carbon quaternary stereocenters and vicinal all-carbon quaternary stereocenters was described. Using pentanidium as a catalyst, this double stereoconvergent process afforded substituted products in good enantioselectivities and diastereoselectivities.
This literature about this compound(1116-98-9)SDS of cas: 1116-98-9has given us a lot of inspiration, and I hope that the research on this compound(tert-Butyl 2-cyanoacetate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem