Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 58656-04-5, is researched, Molecular C18H34BF4P, about Sequential C3 and C5 Direct C-H Arylation of Imidazo[1,2-a]pyrazines with (Hetero)aryl Bromides, the main research direction is regioselective arylation imidazopyrazine aryl heteroaryl bromide.HPLC of Formula: 58656-04-5.
An efficient reaction manifold for the preparation of C3/C5-diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C-H functionalization event. E.g., in presence of Pd(OAc)2, tricyclohexylphosphonium tetrafluoroborate, PivOH, and K2CO3 in DMF under a flow of N2, arylation of imidazo[1,2-a]pyrazine with 1-bromo-4-(ethylthio)benzene gave the C3 aryl product I (56%). Arylation of I with 4-bromoisoquinoline in presence of Pd(OAc)2, 1,10-phenanthroline, and Cs2CO3 gave 35% C3/C5-diaryl product II.
This literature about this compound(58656-04-5)HPLC of Formula: 58656-04-5has given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem