COA of Formula: AuCl4H7O3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about An ultrasound activated vesicle of Janus Au-MnO nanoparticles for promoted tumor penetration and sono-chemodynamic therapy of orthotopic liver cancer. Author is Lin, Xiahui; Liu, Shuya; Zhang, Xuan; Zhu, Rong; Chen, Shan; Chen, Xiaoyuan; Song, Jibin; Yang, Huanghao.
Sonodynamic therapy (SDT) has the advantages of high penetration, non-invasiveness, and controllability, and it is suitable for deep-seated tumors. However, there is still a lack of effective sonosensitizers with high sensitivity, safety, and penetration. Now, ultrasound (US) and glutathione (GSH) dual responsive vesicles of Janus Au-MnO nanoparticles (JNPs) were coated with PEG and a ROS-sensitive polymer. Upon US irradiation, the vesicles were disassembled into small Janus Au-MnO nanoparticles (NPs) with promoted penetration ability. Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleation sites and Mn2+ for chemodynamic therapy (CDT), resulting in enhanced reactive oxygen species (ROS) generation. This also allowed dual-modality photoacoustic imaging in the second near-IR (NIR) window and T1-MR imaging due to the released Mn2+, and inhibited orthotopic liver tumor growth via synergistic SDT/CDT.
From this literature《An ultrasound activated vesicle of Janus Au-MnO nanoparticles for promoted tumor penetration and sono-chemodynamic therapy of orthotopic liver cancer》,we know some information about this compound(16961-25-4)COA of Formula: AuCl4H7O3, but this is not all information, there are many literatures related to this compound(16961-25-4).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem