Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 58656-04-5, is researched, SMILESS is F[B-](F)(F)F.[PH+](C1CCCCC1)(C2CCCCC2)C3CCCCC3, Molecular C18H34BF4PJournal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Synthesis of 2,5-Diaryl Substituted Thiophenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and Cytotoxicity, Author is Hassanpour, Avid; De Carufel, Carole Anne; Bourgault, Steve; Forgione, Pat, the main research direction is diarylthiophene preparation modulation islet amyloid polypeptide amyloid fibril formation; thiophene diaryl preparation helix mimetic; CH arylation; amyloids; decarboxylative arylation; peptidomimetics; thiophenes.Electric Literature of C18H34BF4P.
A range of 2,5-diarylated thiophenes were synthesized as small mol. mimetics of the α-helix to modulate the amyloidogenesis and cytotoxic effect of islet amyloid polypeptide (IAPP). 3-Substituted thiophene-2-carboxylic acids were used as key intermediates and functionalized by palladium decarboxylative cross-coupling and direct C-H activation successively with overall yields ranging from 23 to 95 %. The effect of the ligands on IAPP amyloid fibril formation was evaluated with the thioflavin T (ThT) fluorescence-based assay. Furthermore, the capacity of these compounds to inhibit the cytotoxic effect of IAPP was assessed using β-pancreatic cells.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem