Month: March 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Synthesis and biological evaluation of new antitubulin agents containing 2-(3′, 4′, 5′ – trimethoxyanilino)-3,6-disubstituted-4,5,6,7- tetrahydrothieno[2,3-c]pyridine Scaffold.Quality Control of tert-Butyl 2-cyanoacetate.

Two novel compounds 4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 4,5,6,7-tetrahydrobenzo[b]thiophene I [X = CH, N; R1 = CN, CO2Me, CO2Et, CO2t-Bu; R2 = Me, COMe, CO2Me, CO2Et, C6H5] were synthesized by the reaction of 3′,4′,5′ -trimethoxyanilino moiety and a cyano or an alkoxycarbonyl group at its 2- or 3-position, resp., and evaluated for antiproliferative activity on a panel of cancer cell lines and for selected highly active compounds, inhibition of tubulin polymerization and cell cycle effects. The comps. I [X = N, R1 = CN, R2 = CO2Me, CO2Et] had identified as new antiproliferative agents that inhibited cancer cell growth with IC50= 1.1 to 4.7μM against a panel of three cancer cell lines. Their interaction with tubulin at micromolar levels leads to the accumulation of cells in the G2/M phase of the cell cycle and to an apoptotic cell death. The cell apoptosis study found that compounds I [X = N, R1 = CN, R2 = CO2Me, CO2Et] were very effective in the induction of apoptosis in a dose-dependent manner. These two derivatives I [X = N, R1 = CN, R2 = CO2Me, CO2Et] did not induce cell death in normal human peripheral blood mononuclear cells, suggesting that they may be selective against cancer cells. Mol. docking studies confirmed that the inhibitory activity of these mols. on tubulin polymerization derived from binding to the colchicine site.

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Imidazole – Wikipedia,
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Electric Literature of C8H9NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Entropy, enthalpy, and side arm porphyrins. 1. Thermodynamics of axial ligand competition between 3-picoline and a series of 3-pyridyl ligands covalently attached to zinc tetraphenylporphyrin.

A series of 5-coordinate Zn tetraphenylporphyrins, each with a covalently attached 3-pyridyl side chain of different length, were prepared NMR spectroscopy was used to study the displacement of the 3-pyridyl ligand by free 3-picoline in toluene-d8 solution Values of Keq, ΔH, and ΔS were dependent on the number of atoms in the chain. In all cases, 3-picoline formed a stronger bond with these Zn porphyrins than did the covalently attached pyridyl ligands. The entropy of free internal rotation of the atoms of the uncoordinated pyridyl side chain was an important factor in the entropy of displacement of the covalently attached pyridyl group. Measurement of the thermodn. quantities for 3-picoline addition to a series of structurally related 4-coordinate Zn porphyrins revealed the importance of bulky groups in preventing tight solvation of the porphyrin ring in the region of the binding site, thus increasing the stability and bond strength of the 3-picoline complex.

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SDS of cas: 16961-25-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Dose-dependent efficacy of gold clusters on rheumatoid arthritis therapy. Author is Yuan, Qing; Zhao, Yao; Cai, Pengju; He, Zhesheng; Gao, Fuping; Zhang, Jinsong; Gao, Xueyun.

Chronic inflammation and progressive bone damage in joints are two main pathol. features of rheumatoid arthritis (RA). We have synthesized a gold cluster with glutathione (Au29SG27) (named GA) that can effectively suppress both inflammation and bone damage in collagen-induced arthritis (CIA) in rats. Thus, gold clusters showed great potential for the therapy of RA. However, the optimal therapeutic dose remaining has to be determined Therapeutic effect and safety are largely relying on drug dosage. Specifying the dose-dependent effects of GA on both therapy and biosafety can facilitate its clin. transformation research. Therefore, in this study, we comprehensively evaluated the dose-dependent efficacy of GA on the 30-day toxicity and RA treatment in rats. Results showed that continuous i.p. injection of GA at a dose of 15 mg/kg (Au content) for 30 days resulted in slight hematol. abnormalities and increases on organ coefficients of kidney and adrenal gland, while 10 mg Au/kg did not cause any obvious toxicity and side effects. In the treatment of CIA rats, only when the dose of GA reached 5 mg Au/kg, the symptoms of RA could be significantly improved. With regard to the histopathol. anal., although a lower dose of GA can suppress inflammation and bone damage to some extent, only the 5 mg Au/kg treatment could restore them to a state close to the normal control group. Therefore, we infer that 5 mg Au/kg is the optimal dose of GA for RA therapy in rats, which provides a theor. basis for further preclin. research.

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Application In Synthesis of Tricyclohexylphosphonium tetrafluoroborate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Design and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions. Author is Iaroshenko, Viktor O.; Ostrovskyi, Dmytro; Miliutina, Mariia; Maalik, Aneela; Villinger, Alexander; Tolmachev, Andrei; Volochnyuk, Dmitriy M.; Langer, Peter.

A new strategy for the synthesis of polycyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)-catalyzed intramol. arylation via CH/C-Hal and CH/CH coupling reactions, was developed (e.g., I → II). The method proposed here enables the synthesis of many fused N-heterocycles containing purine, 1-deazapurines and benzimidazole structural units.

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Product Details of 1116-98-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction. Author is Zhang, Xin; Ren, Jingyun; Tan, Siu Min; Tan, Davin; Lee, Richmond; Tan, Choon-Hong.

Bimol. nucleophilic substitution (SN2) plays a central role in organic chem. In the conventionally accepted mechanism, the nucleophile displaces a carbon-bound leaving group X, often a halogen, by attacking the carbon face opposite the C-X bond. A less common variant, the halogenophilic SN2X reaction, involves initial nucleophilic attack of the X group from the front and as such is less sensitive to backside steric hindrance. Herein, we report an enantioconvergent substitution reaction of activated tertiary bromides by thiocarboxylates or azides that, on the basis of exptl. and computational mechanistic studies, appears to proceed via the unusual SN2X pathway. The proposed electrophilic intermediates, benzoylsulfenyl bromide and bromine azide, were independently synthesized and shown to be effective.

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Imidazole – Wikipedia,
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Tan, Wen-Yun; Lu, Yi; Zhao, Jing-Feng; Chen, Wen; Zhang, Hongbin published an article about the compound: 3-Pyridinepropionic acid( cas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1 ).Reference of 3-Pyridinepropionic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3724-19-4) through the article.

In this paper,a new chemoselective process for the oxidation of primary alcs. and aldehydes was reported. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcs. and tert-butanesulfinamides.

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Imidazole – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Studies of furan derivatives. I. Synthesis of chlorofuran derivatives, published in 1958, which mentions a compound: 58235-81-7, Name is Methyl 5-chlorofuran-2-carboxylate, Molecular C6H5ClO3, HPLC of Formula: 58235-81-7.

Tetrachloro-2-furoic acid (I) dissolved in methanol, dropped into methanolic NaOH solution, previously chilled below 0°, with stirring, the mixture kept 24 hrs., and methanol removed under reduced pressure, gave 3,4-dichloro-2-furoic acid (II), m. 167-8° (dilute EtOH). II (8 g.) heated in 50 cc. water at 100°, 20 g. 1% Na-Hg added gradually, and the mixture kept at 100° for 1 hr. with stirring, cooled, and acidified deposited 3.8 g. 3-chloro-2-furoic acid (III), m. 148-9° (water). III yielded a chloride (IV) with SOCl2. IV added 1 mole Cl; the mixture was distilled at room pressure, the fraction b. 180-20° gradually added to a cold ethanolic solution of NaOH with stirring, the deposit filtered off, and dissolved in water, and the solution acidified with HCl to give 5-chloro-2-furoic acid (V), yield 4%, m. 176-7° (dilute MeOH). A similar run with Me 5-chloro-2-furoate (VI), which was prepared from 30 g. V, 60 cc. ethanol, and 15 g. concentrated H2SO4, gave 3,5-dichloro-2-furancarboxylic acid (VII) in 22% yield, m. 155-6° (dilute methanol). The acid chloride of II (8 g.), heated with 0.8 g. Pd-BaSO4 (5%) and 75 cc. dry xylene in 140-5° oil bath while passing H with stirring, gave 3,4-dichlorofurfural in 83% yield, m. 52-3°. A similar run with the chlorides of III, VI, and VII gave 3-chlorofurfural (VIII), 60%, m. 28°, 5-chlorofurfural, 7%, m. 31-3%, and 3,5-chlorofurfural, 59%, m. 11-13°, b4 59-61°, resp.

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Imidazole – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, is researched, Molecular C7H5BrClF, CAS is 206362-80-3, about Discovery of novel, potent, isosteviol-based antithrombotic agents.Quality Control of 4-(Bromomethyl)-1-chloro-2-fluorobenzene.

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (Ki = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents. Here is a brief introduction to this compound(206362-80-3)Quality Control of 4-(Bromomethyl)-1-chloro-2-fluorobenzene, if you want to know about other compounds related to this compound(206362-80-3), you can read my other articles.

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Imidazole – Wikipedia,
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Application of 16961-25-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Synthesis of ultra-small gold nanoparticles by polyphenol extracted from Salvia officinalis and efficiency for catalytic reduction of p-nitrophenol and methylene blue. Author is Oueslati, Mohamed Habib; Ben Tahar, Lotfi; Abdel Halim Harrath.

The present research work reports an eco-friendly route for preparing gold nanoparticles (AuNPs) with high catalytic activity using polyphenol extracted from salvia officinalis. In both alk. (pH ∼ 11) and acidic media (pH ∼ 5), the polyphenol induced rapid reduction of the Au (III) salt and lead to the formation of highly monodisperse and spherical small (S) and larger (L) AuNPs, resp. The average particle size was found to be ∼ 6 nm for S and ∼ 27 nm for L AuNPs, resp. FT-IR revealed that polyphenol species are capped onto the nanoparticles surface favorizing a high aqueous colloidal stability of the AuNPs in a wide pH range. In addition, the produced AuNPs exhibited significant size-dependent degradation rate of p-nitrophenol (p-NP) and methylene blue (MB) to p-aminophenol (p-AP) and leucomethylene blue (LMB), resp.

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Related Products of 3724-19-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity. Author is Reddy, K. Papi; Bid, Hemant K.; Nayak, V. Lakshma; Chaudhary, Preeti; Chaturvedi, J. P.; Arya, K. R.; Konwar, Rituraj; Narender, T..

The taxane diterpenoid 2-deacetoxytaxinine J (2-DAT-J; I) has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J showed significant in vitro activity against breast cancer cell line at a concentration of 20 μM and 10 μM in MCF-7 and MDA-MB-231 resp. A few novel taxoids were derived from the naturally occurring 2-DAT-J and screened for their anticancer activity. The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10 mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p < 0.05). Here is a brief introduction to this compound(3724-19-4)Related Products of 3724-19-4, if you want to know about other compounds related to this compound(3724-19-4), you can read my other articles.

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Imidazole – Wikipedia,
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