Application of 1116-98-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about CuI/I2-Catalyzed Concise Synthesis of Substituted 6-Aminoisoquinolinoquinazoline Carboxylates from Anthranilamide. Author is Gal Reddy, Potuganti; Reddy Indukuri, Divakar; Alla, Manjula.
A one pot sequential addition protocol for synthesis of polycyclic quinazolines with β-amino acid motifs has been achieved starting from anthranilamide. Initial in situ formation of 2-(2-bromophenyl)quinazolin-4(3H)-one followed by addition of alkyl cyanoacetates catalyzed by copper (I) salts gives the target compound in good to excellent yields. The expedient and facile cascade protocol involves nucleophilic α-arylation, intramol. cycloamidation of nitriles followed by 1,3-hydrogen shift allowing direct access to 6-amino-8-oxo-8H-isoquinolino[1,2-b]quinazoline-5-carboxylates I (R = CN, COOMe, COOt-Bu, COOBn, etc.; R1 = H, 10-Cl, 10-F; R2 = H, 2-F, 3-Me, etc.).
If you want to learn more about this compound(tert-Butyl 2-cyanoacetate)Application of 1116-98-9, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1116-98-9).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem