So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nguyen, Thanh Binh; Mac, Dinh Hung; Retailleau, Pascal researched the compound: tert-Butyl 2-cyanoacetate( cas:1116-98-9 ).Safety of tert-Butyl 2-cyanoacetate.They published the article 《Base-Catalyzed Three-Component Reaction of α-Cyanoacetates with Chalcones and Elemental Sulfur: Access to 2-Aminothiophenes Unobtainable via the Gewald Reaction》 about this compound( cas:1116-98-9 ) in Journal of Organic Chemistry. Keywords: cyanoacetate chalcone sulfur DABCO catalyst three component reaction; aminothiophene preparation. We’ll tell you more about this compound (cas:1116-98-9).
Although the Gewald reaction was well-known for more than half a century as an excellent method providing bioactive 2-aminothiophenes from reactions of α-cyanoacetates and carbonyl compounds and elemental sulfur, its application to dibenzoylmethanes as the carbonyl substrates was, however, unknown and exptl. proven unsuccessful. Here a convenient approach to such a series of compounds by a DABCO-catalyzed, one-pot, two-step, three-component reaction of α-cyanoacetate with chalcones and elemental sulfur was proposed. This catalytic strategy was highlighted by its excellent atom/step efficiency and high degree of structural diversification by simply choosing the suitable starting chalcones, which were unarguably much more readily available than dibenzoylmethanes.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem