Electric Literature of 288-32-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288-32-4 name is 1H-Imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The starting material was prepared as follows: Imidazole (20.4 g, 300 mmol) and ethylene carbonate (28.6 g, 325 mmol) were heated at 125 C. for 1 hour. Once the CO2 evolution had ceased the reaction mixture was allowed to cool to ambient temperature, was suspended in methylene chloride/methanol (10/1, 50 ml) and was placed on the top of a short plug of silica. Elution was done using an increasingly polar solvent mixture of methylene chloride/methanol (100/10 up to 100/15). Removal of the solvent by evaporation gave crude 2-(imidazol-1-yl)ethanol (20.1 g, 60%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Zeneca Limited; US6294532; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem