Application of 68282-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
COMPOUND 12.1.58: N,N-DIETHYL-4-{5,6,7-TRIMETHOXY-2-[(2-PHENYL- 1H-IMIDAZOL-5-YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-1- YLIBENZAMIDE; 2-Phenyl-imidazole-4-carboxyaldehyde (92.6 mg, 0.54 mmol) was added to a solution of INTERMEDIATE 5.1. 16 (107.7 mg, 0.27 mmol) in 1,2-dichloroethane (5 mL) and the reaction mixture stirred at room temperature for 10 min. Sodium triacetoxyborohydride (400 mg, 1.89 mmol) was added followed by N-methyl-2- pyrrolidinone (350 pL) and the reaction mixture stirred at RT for 16 h. 1 N NaOH (5 mL) was added and the organic solvent removed in vacuo. The residue was extracted with EtOAc (3 x 20 mL) and the organic layer washed with water (20 mL). The organic layer was concentrated in vacuo and the residue purified by flash chromatography on SiOx column (EtOAc: MeOH 95: 5) to afford COMPOUND 12.1. 58 as an oil (33 mg, 22%). lH NMR (500 MHz, CDC13) : 8 1.10 (br s, 3H), 1.24 (br s, 3H), 2.63 (m, 1H), 2.76 (m, 2H), 3. 10 (m, 1H), 3.26 (br s, 2H), 3.57 (s, 3H), 3.51-3. 62 (m, 4H), 3.84 (s, 3H), 3. 88 (s, 3H), 4.65 (s, 1H), 5.98 (s, 1H), 6.91 (s, 1H), 7.25-7. 35 (m, 7H), 7.87 (d, J 8.5 Hz, 2H) ; 13C NMR (125 MHz, CDCl3) : 6 13.12, 14.45, 22. 51, 39.70, 43.67, 46.18, 49.68, 56.09, 60.70, 61.03, 66. 58, 107.94, 121.56, 125.43, 126.50, 128.46, 128.90, 129.91, 130. 76, 132. 78,136. 08,140. 72,144. 76, 146.76, 147.07, 150. 89, 151. 73, 171.64 ; (+) LRESIMS m/z 555.25 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem