In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1243204-92-3, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile
3- Methoxy-4-(4-methyl-1 /-/-imidazol-1-yl)benzonitrile (46.9 g, 0.22 mol), in methanol (176 ml_) and water (88 ml_), were treated with potassium hydroxide (85%, 16.5 g, 0.25 mol) and the resulting solution was refluxed for 72 hours. The solution was concentrated in vacuo to approximately 100 ml_, and the resulting solid was removed by filtration. Water (40 ml_) was added to the filtrate, which was then acidified to pH 5 by addition of small portions of 30% aqueous hydrochloric acid (approximately 40 ml_). The resulting thick suspension was heated to reflux for 5 minutes and left to cool overnight. The mixture was filtered, and the white solid was washed with water (3 x 20 ml_) and dried in vacuo to afford the title compound as a white powder. Yield: 53.76 g, 0.231 mmol, quantitative. LCMS m/z 233.1 (M+1 ). 1H NMR (300 MHz, CD3OD) 5 2.36 (d, J=1.0 Hz, 3H), 3.97 (s, 3H), 7.43 (m, 1H), 7.56 (d, J=8.2 Hz, 1 H), 7.76 (dd, J=8.1 , 1.7 Hz, 1 H), 7.84 (d, J=1.6 Hz, 1 H), 8.66 (d, J=1.5 Hz, 1 H).
The synthetic route of 1243204-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; ALLEN, Martin, Patrick; AM ENDE, Christopher, William; BRODNEY, Michael, Aaron; DOUNAY, Amy, Beth; JOHNSON, Douglas, Scott; PETTERSSON, Martin, Youngjin; SCHWARZ, Jacob, Bradley; TRAN, Tuan, Phong; WO2010/100606; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem