Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
The solution of 5g (130mg, 0.291 mmol) in THF (3ml) in ice- H2O bath was added IprMgCI UCI (1.3M in THF) solution (336mul, 0.437mmol), the mixture was kept stirring for 30 min at O0C before the addition of compound 1d (75mg, 0.350mmol), the resultant mixture was kept stirring at O0C for 2h. EtOAc (10ml) and NH4CI (6ml) were added, the aqueous was extracted once more with EtOAc (6ml). The combined organic was washed with brine (6ml), dried over anhydrous MgSO4, and concentrated. The residue was purified via ISCO (DCM/ MeOH (2N NH3) = 25:1) to 5h as a yellow solid (132mg). MH+ 584
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SCHERING CORPORATION; WO2009/73777; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem