Reference of 693-98-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 693-98-1 as follows.
Step 3aIodine (18.5 g, 73.1 mmol) was dissolved in 90 mL of chloroform. 2-Methylimidazole (3.0 g, 36.5 mmol) in 90 mL of 2M NaOH solution was added slowly.The cloudy mixture cleared to two phases by 2.5 h.The layers were separated and acetic acid (10.5 mL, 183 mmol) was added to the organic layer to neutralize the reaction (to pH~5-6).A solid appeared which was filtered off and recrystallized from warm acetonitrile to afford 8.5 g (69percent) of 4,5-diiodo-2-methyl-1H-imidazole. (M+H)+=334.
According to the analysis of related databases, 693-98-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael; US2011/230462; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem