Electric Literature of 14741-71-0, A common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of compound (4a-b) (4 g, 0.022 mol) in absoluteethanol (15 mL) was refluxed for 7 h in presence of conc. H2SO4(0.1 mL). After completion of the reaction, it was cooled to roomtemperature, then 2.14 ml (0.044 mol) of hydrazine hydrate wasadded and the reaction was further refluxed for another 8 h.Detecting single-spot in TLC using the solvent system chloroform:methanol (9:1), the reaction mixture was poured in ice. A precipitateformed (6a-b) which was filtered, washed with water andcrystallized from ethanol. 4.4.1. 2-(1H-benzo[d]imidazol-2-yl)acetohydrazide (6a, C9H10N4O)white flakyYield 86%, mp 120-122 C; Rf 0.40 [chloroform: methanol(9:1)]; IR (KBr) (cm1): 3360 (NH str), 1733 (C]O); 1H NMR(300 MHz, DMSO-d6) delta(ppm): 3.66 (s, 2H, NH2), 4.28 (s, 2H, CH2C] O), 7.11e7.12 (d, 2H, J 3.6, H-5,6 benzimidazole), 7.47 (s, 2H, H-4,7benzimidazole), 9.36 (s, 1H, eNHNH2), 12.22 (bs, 1H, NH benzimidazole,D2O exchangeable). 13C NMR (75 MHz, DMSO-d6) delta(ppm): 164.38, 149.56, 137.68, 133.50, 125.50, 121.27, 45.06. Anal.Calcd.: C, 56.83; H, 5.30; N, 29.46; Found: C, 56.85; H, 5.34; N, 29.43.
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Akhtar, Md Jawaid; Siddiqui, Anees Ahmad; Khan, Ahsan Ahmed; Ali, Zulphikar; Dewangan, Rikeshwer Prasad; Pasha, Santosh; Yar, M. Shahar; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 853 – 869;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem