14-Sep-2021 News Share a compound : 53484-18-7

The synthetic route of 53484-18-7 has been constantly updated, and we look forward to future research findings.

Application of 53484-18-7, These common heterocyclic compound, 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1 (50 mg, 0.28 mmol), tert-butyl 2-amino-4-(thiophen-2- yl)phenylcarbamate (66 mg, 0.23 mmol), and EDCI (164 mg, 0.85 mmol) were combined in Py (3 ml_). The reaction was stirred at rt overnight. After completed, the mixture was concentrated and washed with water and ether. The white solid was afforded as Compound 2 (100 mg, 72%).

The synthetic route of 53484-18-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REGENACY PHARMACEUTICALS, LLC; VAN DUZER, John, H.; MAZITSCHEK, Ralph; BLUM, Charles; (70 pag.)WO2020/68950; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem