Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methyl-1H-imidazole-2-carboxylic acid
A solution of Intermediate II (30 mg, 0.092 mmol) and 1-methyl-1H-imidazole- 2-carboxylic acid (14 mg, 0.11 mmol) in 1 mE of DMF was treated at 0 C with i-Pr2NEt (0.10 mL, 0.57 mmol) and propane phosphonic acid anhydride (T3P; 0.11 mL, 0.25 mmol). The vialwas sealed and stirred at room temperature ovemight. The reaction mixture was filtered, washing the filter with DMSO (1 niL). The crude product dissolved in 2 mL of DMSO/DMF was purified by reverse phase HPLC. The desired fraction was concentrated under reduced pressure to yield 2-39. ?Ii NMR (600 MHz, DMSO-d6) 3 8.48 (m, 1 H), 7.96 (m, 1 H), 7.28 (m, 1 H), 6.96 (m, 1 H), 5.88 (s, 1 H), 4.14 (q, J= 7.2 Hz, 2 H), 3.82 (s, 3 H), 3.80 (s, 3 H), 4.00-3.60(m, 4 H), 2.53-2.52 (m, 3 H), 2.35-2.20 (m, 2 H), 1.32 (t, J= 7.3 Hz, 3 H); MS (El) Calc?d for C21H26N902 [M+Hfb, 436; found 436.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20485-43-2.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; GUZI, Timothy; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; MU, Changwei; ZHANG, Sixing; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75392; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem