934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 934-32-7
In a 50 mL single-mouth eggplant bottle, 0.55 g (4.1 mmol) of 1H-benzo[d]imidazol-2-amineDissolve in 15 mL of acetone, add 0.70 g (12 mmol) of potassium hydroxide powder and 1.1 g (8.2 mmol) of potassium carbonate, stir at room temperature for 10 min, transfer to ice water bath, add 0.45 mL (4.5 mmol) 2-iodopropane dropwise, and move to Stir in a 65 C oil bath for 3 h.The reaction was detected by TLC, the reaction solution was diluted with EA, the solid was filtered off, the solvent was evaporated, the solvent was evaporated, 10 mL of water was added, and extracted with EA (8 mL*3, combined organic phase, dried over Na2SO4, concentrated, flash silica gel column chromatography (gradient wash) De DCM: MeOH = 100:1 to 30:1) to give 275 mg of pale yellow solid.Yield 38%
The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Anyanren Pharmaceutical Technology Co., Ltd.; Xie Dexun; Li Quanwei; Xue Weicai; Liu Hui; (27 pag.)CN108912095; (2018); A;,
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