Adding a certain compound to certain chemical reactions, such as: 3543-73-5, name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3543-73-5, Computed Properties of C14H19N3O2
Example-5 Preparation of Ethyl 4-{5-[bis(2-hydroxyethyI)amino]-l-methyl-lH-benzimidazol- 2-yl} butanoate (III) Ethyl 4-[5-amino-l -methyl- l H-benzimidazol-2-yl)butanoate (II, 200.0g, 0.763mol) was added to DM Water (1.1L). Aqueous sodium acetate.3H20 (20.0g sodium acetate.3H20 in lOOmL DM water) and acetic acid (400mL) was added and agitated till complete dissolution of compound of the formula II. The reaction mixture was cooled to 0-5C and ethylene oxide (270. Og, 6.12mole) was added maintaining the temperature of the reaction mixture at 0-5C. The reaction mixture was stirred at 0-5C for 5 hours. The temperature of reaction mixture was raised to 20-25C and agitated at 20-25C for 18 hours. After completion of the reaction, dichloromethane (2.0L) was added at 20-25C followed by addition of aqueous solution of potassium carbonate (440. Og potassium carbonate in 1.1L DM water) portion wise at 20-25C to control the evaluation of effervescence and agitated at 20-25C for 5-10 minutes. The layers were separated. The organic layer (dichloromethane) was washed with DM water (1.0L) twice and organic layer was concentrated under vacuum at 40-50C till viscous mass is obtained. The viscous mass was dissolved in acetone (1.0L), cooled to 0-5C and agitated at 0-5C for 1 hour. The solid separated out was filtered, washed with chilled (0-5C) acetone (200.0mL) and dried at 40-50C under vacuum for 6 hours to give the title compound (III, 210.0g; 78.53%), with a purity of 99.06%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; MISHRA, Bhuwan Bhaskar; KACHHADIA, Nikunj Shambhubhai; TOMAR, Vinod Singh; LAHIRI, Saswata; WO2013/46223; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem