Adding a certain compound to certain chemical reactions, such as: 89830-98-8, name is 5-Cyclopropyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89830-98-8, Quality Control of 5-Cyclopropyl-1H-imidazole
[00400] A mixture of Example 61f (300 mg, 0.63 mmol), Example 61g (204 mg, 1.89 mmol), 8- quinoline (36 mg, 0.25 mmol), Cs2C03(411 mg, 1.26 mmol) and Cu20 (36 mg, 0.25 mmol)in BuCN (5 mL) was stirred at 120°C for 16 h under N2. Then the solution was filtrated and purified by Prep-HPLC, followed by Prep-TLC (DCM/MeOH= 20/1) to give thedesired product Example 61 (6.6 mg, yield 2percent) as a white solid. LCMS [M+l] + = 456.0. NMR (400 MHz, DMSO- 6) delta 11.25 (s, 1H), 8.67 (s, 1H), 8.04 (t, J= 7.9 Hz, 1H), 7.85 (t, J= 7.0 Hz, 2H), 7.76 (s, 1H), 7.62 (s, 1H), 7.34 (s, 1H), 7.10 (s, 1H), 4.37 (m, 2H), 4.25 (t, J= 8.5 Hz, 2H), 2.47 (m, 2H), 2.19 (s, 3H), 1.96 (m, 2H), 1.82 (m, 1H), 0.82-0.73 (m, 2H), 0.69 (d, J= 4.4 Hz, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Cyclopropyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (214 pag.)WO2019/51265; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem