Related Products of 71759-89-2, These common heterocyclic compound, 71759-89-2, name is 5-Iodo-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-iomethyl-1H-imidazole (970 mg, 545 mmoles) in DMF (10 mL) is added NaH 60% dispersion inmineral oil (220 mg, 5.5 mmoles). The reaction mixture isheated at 50 C. for 1 h, then 2-bromoethylbenzene (781 f.LL,5.5 mmoles) and a catalytic quantity oftetrabutylammoniumbromide are added to the mixture. The reaction mixture is50 then heated at 80 C. for 5 hours. Half-saturated ammoniumchloride solution is added, and the aqueous phase is extractedthree times with Et20. The organic phase is washed withwater, brine, dried over magnesium sulphate, filtered and the solvent is removed under reduced pressure. The residue is purified by silica gel chromatography using (heptane:AcOEt)as eluentwithagradientfrom (95:5)to (60:40)to give4-iodo-1-phenethyl-imidazole and 5-iodo-1-phenethyl-imidazole.4-iodo-1-phenethy 1-imidazole1H NMR: 7.38-7.15 (m, 4H), 7.10-6.96 (m, 2H), 6.93 (s,lH), 4.14 (t, J=8.5 Hz, 2H), 3.04 (t, J=8.5 Hz, 2H).5-iodo-1-phenethyl-imidazole1H NMR: 7.41 (s, lH), 7.36-7.18 (m, 3H), 7.15-7.00 (m,3H), 4.15 (t, J=8.6 Hz, 2H), 3.04 (t, J=8.6 Hz, 2H).
Statistics shows that 5-Iodo-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 71759-89-2.
Reference:
Patent; BIOPROJET; Berrebi-Bertrand, Isabelle; Billot, Xavier; Calmels, Thierry; Capet, Marc; Krief, Stephane; Labeeuw, Olivier; Lecomte, Jeanne-Marie; Levoin, Nicolas; Ligneau, Xavier; Robert, Philippe; Schwartz, Jean-Charles; (73 pag.)US9255101; (2016); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem