Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H5ClN2O2S
To a precooled (0 C) solution of intermediate 2.66 (18 mg, 0.074 mmol) and triethylamine (30 muL, 0.2 mmol) in dichloromethane (0.5 mL) was added 1-methyl-1H- imidazole-4-sulfonyl chloride (20. mg, 0.11 mmol). The resulting mixture was allowed to warm to room temperature and stirred for 18 h, then diluted with wet DMSO (1 mL), filtered through Celite and purified via mass-directed isolation using ultra-performance liquid chromatography (6.3 mg, 22% yield).1H NMR (500 MHz, Acetonitrile-d3) d 8.56 (s, 1H), 7.69 (s, 1H), 7.66 (dd, J = 11.8, 2.4 Hz, 1H), 7.59 (d, J = 1.4 Hz, 1H), 7.37 (t, J = 8.6 Hz, 1H), 7.21 (dd, J = 8.7, 2.1 Hz, 1H), 3.72 (s, 3H), 3.63 (dd, J = 10.4, 7.9 Hz, 1H), 3.50- 3.40 (m, 2H), 3.40- 3.32 (m, 1H), 3.00 (p, J = 7.6 Hz, 1H), 2.14- 1.96 (m, 2H); AMM 409.0521 (ESI) m/z [calc for C15H16ClFN4O3SNa (M+Na)+ 409.0513].
According to the analysis of related databases, 137049-00-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VAL-CHUM, LIMITED PARTNERSHIP; GRENIER, Melissa Carey; SMITH, Amos B., III; FINZI, Andres; DING, Shilei; CHAPLEAU, Jean-Philippe; (240 pag.)WO2020/28482; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem