Reference of 934-22-5, The chemical industry reduces the impact on the environment during synthesis 934-22-5, name is 6-Aminobenzimidazole, I believe this compound will play a more active role in future production and life.
Example 12; 1-(6-([(1S)-1-phenylethyl]amino/pyrazin-2-yl)-1H-benzimidazol-5-amine and 1-(6-([(1S)-1-phenylethyl]amino/pyrazin-2-yl)-1H-benzimidazol-6-amine To a stirred solution of 5-amino-benzimidazole (290mg, 2.2mmol) in anhydrous DMF (lOmL) under Ni was added caesium carbonate (980mg) The resulting mixture was stirred at 70’C for 60 min. To this was added a solution of 6-chloro-N- [ (lS)-l- phenylethyllpyrazin-2-amine (470mg) in DMF (5mL) and the resulting mixture was then heated at reflux for 48h. The DMF was removed under reduced pressure and the residue diluted with chloroform.. The organic layer was washed with aqueous Na2CO3, dried (Na2SO4) and the solvent removed under reduced pressure to furnish the crude product. Column chrumatography using dichloromethane-methanol (95 : 5-92 : 8) as eluant separated two fractions from unreacted starting material. The higher Rf fraction was assigned as the 6-isomer (276mg, 42%). 1H-n.m.r. (CDCl3) No.1. 64 (d, 3H, J=6.9Hz, CH3), 2. 90 (br s, 2H, NH2), 5. 05 (m, 1H, CH), 5.21 (d, 1H, NH), 6.70 (dd, 1H, J=8. 7, 2. 1Hz, benzimid-H), 6. 97 (d, 1H, = l. 8Hz, benzimid-H), 7. 28-7. 43 (m, 5H, Ph-H), 7. 58 (d, 1H, J= 8. 4Hz, benzimid-H), 7. 84 (s, IH, pyraz-H), 8.08 (s, 1 pyraz-H), 8. 21 (s, 1H, benzimid-H). m/z (ES) 331 (M++H). The lower fraction was assigned aa the 5-isomer (170mg, 26%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Aminobenzimidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CYTOPIA RESEARCH PTY LTD; WO2005/66156; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem