Reference of 53710-78-4, The chemical industry reduces the impact on the environment during synthesis 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.
General procedure: To a solution of 24 (53 mg, 0.1 mmol) in DMF (25 mL), 60% NaH (4.2 mg, 0.105 mmol) was added portionwise at room temperature. After stirring for 30 min, alkyl halide (0.15 mmol) was added and the mixture was then reacted at 80 C for 10h. After cooling, the mixture was poured into water (100 mL) and extracted with ethyl acetate (3×50mL). The organic phase was combined, washed with brine (3×100mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 28d and 28e.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ye, Qing; Shen, Yanhong; Zhou, Yubo; Lv, Dan; Gao, Jianrong; Li, Jia; Hu, Yongzhou; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 361 – 371;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem