Synthetic Route of 1849-01-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1849-01-0 name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Prepared from 1 -methyl-1,3-dihydro-2H-benzimidazol-2-one (100 mg, 0.6720 mmol), 2-bromo-5-(difluoromethyl-1,3,4-oxadiazole (134.3 mg, 0.67 mmol), potassiumcarbonate (280 mg, 2.02 mmol), copper iodide (12.9 mg, 0.07 mmol) and trans-/V,/Vdimethylcyclohexane-1,2-diamine (0.02 ml_, 0.1400 mmol) in 1,4-dioxane (5 ml.) at 80 C for2 h. Product obtained as a white solid (65 mg, 0.24 mmol, 36%).[00483] 1H NMR (300MHz, DMSO-d6) Shift = 7.88 (d, J=7.6 Hz, 1H), 7.76 – 7.38 (m,25 1 H), 7.38 – 7.32 (m, 2H), 7.31 – 7.22 (m, 1H), 3.41 (s, 3H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; MCGONAGLE, Alison E.; JORDAN, Allan M.; WASZKOWYCZ, Bohdan; HUTTON, Colin P.; WADDELL, Ian D.; HITCHIN, James R.; SMITH, Kate M.; HAMILTON, Niall M.; (265 pag.)WO2016/97749; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem