Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32673-41-9, name is 4-Imidazolemethanol hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Imidazolemethanol hydrochloride
Referential Example 8 4-(Dichloromethyl)-2-(4-(hydroxymethyl)imidazole-1-yl)-5-nitro-benzotrifluoride To a solution of the compound of Referential example 7 (5.31 g, 18.2 mmol) in tetrahydrofuran (40 ml) were added 4-(hydroxymethyl)imidazole hydrochloride (4.90 g, 36.4 mmol) and triethylamine (7.37 g, 72.8 mmol), and the mixture was refluxed for 1.5 hours. After cooling, ethyl acetate was added to the reaction mixture, washed with brine, then dried over anhydrous magnesium sulfate and solvent was distilled off. The residue obtained was submitted to silica gel column chromatography [ethyl acetate-hexane(3:1)?ethyl acetate] to obtain 5.15 g of title compound as pale yellow powder. Yield 76%. 1H-NMR(DMSO-d6, delta): 4.44(2H,d,J=4.4 Hz), 5.09(1H,t,J=4.4 Hz), 7.39 (1H,s), 7.78(1H,s), 7.92(1H,s), 8.19(1H,s), 8.59(1H,s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; US6562839; (2003); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem