Reference of 7098-07-9,Some common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A generic experimental procedure is described: N-substituted imidazoles 1-6 (1 mmol equivalent) and 2,6-bis(chloromethyl)pyridine 7 (0.5mmol equivalent for each compound, m.p 73-78 °C; ALDRICH) were mixed together under inert condition in a 50 ml round bottom flask with gentle stirring. The temperature was then gently raised to 60 °C; giving a molten substance that was allowed to continue stirring for 16 h at 60 °C. The resultant grey or light brown crude solid was allowed to cool to room temperature and loaded onto a short plug of silica. Unreacted starting materials are rinsed-out with ethyl acetate while the salts were obtained (Rf value 0.01) as methanol (100percent) eluents. Solvent is then removed under reduced pressure to yield pure imidazolium salts 8-13.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Ethyl-1H-imidazole, its application will become more common.
Reference:
Article; Ibrahim, Halliru; Bala, Muhammad Dabai; Tetrahedron Letters; vol. 55; 46; (2014); p. 6351 – 6353;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem