In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 60-56-0 as follows. name: 1-Methyl-1H-imidazole-2(3H)-thione
Add 1-methylimidazole-2-thiol (0.25 g, 2.16 mmol) to a 50 mL round bottom flaskAnd potassium carbonate (0.89g, 6.48mmol) (20mL) in acetonitrile was stirred at room temperature for 1 hour and nitrogen.Intermediate IX (0.70 g, 2.16 mmol) was then added to the reaction mixture.Stirring was carried out at 80 C for 12 hours under reflux. Thin layer chromatography was followed until the end of the reaction.The solvent is distilled off under reduced pressure, and then concentrated, extracted, and separated by column chromatography.After drying and the like, the compound IV (400 mg) was obtained in a yield of 51.7%.White solid, melting point > 250 C.
According to the analysis of related databases, 60-56-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Southwest University; Zhou Chenghe; Ba Tini·nasaiya; Li Zhenzhen; (17 pag.)CN109535176; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem