In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-56-4, name is 2-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 16681-56-4
To 2-bromo-lH-imidazole (0.073 g, 0.5 mmol), 3-(bromomethyl)pyridine hydrobromide (0.139 g, 0.550 mmol) and potassium carbonate (0.223 g, 1.614 mmol) was added acetone (15 mL). This mixture was stirred for 18 h at RT. The solvent was then removed in vacuo yielding a brown residue. This residue was then partitioned between ethyl acetate (35 mL) and water (35 mL) and the phases separated. The aqueous phase was then extracted twice with ethyl acetate (2×35 mL), the organics combined and then dried using a hydrophobic frit. The solvent was then removed in vacuo yielding a yellow oil as the title compound (107 mg, 0.449 mmol, 90%). LCMS (System B): tRET = 0.56 min; MH+ 238, 240.
The synthetic route of 16681-56-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; BAXTER, Andrew; BIT, Rino, Antonio; BROWN, John, Alexander; HIRST, David; HUMPHREYS, Philip; JONES, Katherine, Louise; PATEL, Vipulkumar, Kantibhai; (124 pag.)WO2018/41964; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem