Application of 4856-97-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4856-97-7 as follows.
To 1.2 eq. (2.3 g, 0.041 mol) of KOH dissolved in a 50percent (v/v) water?ethanol mixture (14 mL), 5.1 g (0.034 mol) of 1-(1H-benzimidazol-2-yl) methanol was added. The solution was cooled to 0 °C, and 5 mL of dimethyl sulfate was added dropwise over 30 min (the temperature of the mixture did not exceed 5 °C). The mixture was kept under stirring at 0 °C for 30 min and at room temperature for additional 15 min. The solid obtained was recovered by filtration and washed with water, giving the title compound as a white solid. It was purified by recrystallization from a mixture of CH3CN/EtOH. White solid; Yield: 4 g (72percent); M.p. 122?124 °C; 1H NMR (250 MHz, CDCl3): delta 7.76?7.64 (m, 1H), 7.29?7.19 (m, 3H), 5.13 (OH, br s, 1H), 4.88 (CH2, s, 2H), 3.81 (N-CH3, s, 3H); FT-IR (4000?600 cm?1): 3450?2800, 1639, 1454, 1312, 1007, 860, 744, 567; UV?vis (MeOH) (lambdamax, nm (logepsilon, M?1 cm?1): 280(5.35), 268(5.18), 244(5.14), 219(5.06).
According to the analysis of related databases, 4856-97-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Benhassine, Anfel; Boulebd, Houssem; Anak, Barkahem; Bouraiou, Abdelmalek; Bouacida, Sofiane; Bencharif, Mustapha; Belfaitah, Ali; Journal of Coordination Chemistry; vol. 71; 2; (2018); p. 311 – 328;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem