Synthetic Route of 16681-59-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.
Compound A1 (16.1 g, 100 mmol) was sequentially added to the flask under argon gas protection.Compound B1 (12.3 g, 105 mmol), Pd(PPh3) 4 (2.31 g, 2 mmol),Toluene (300 ml), aqueous sodium carbonate (2M, 150 ml),Stir under reflux for 8 hours. After cooling the above reaction solution to room temperature,Extract with toluene and combine the organic phases.The organic phase is washed with saturated brine, and the organic phase is dried and concentrated.Column chromatography was carried out using silica gel as a stationary phase to give Compound D1.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1-methyl-1H-imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Han Chunxue; Sun Jing; (31 pag.)CN108892690; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem