Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C5H6N2O
COMPOUND 12. 1.21 : N, N-DIETHYL-4-E1, 2, 3, 4-TETRAHYDRO-6-METHOXY-2- [ 4-METHYL-lH-IMIDAZOL-5-YL) METHYLI-1-ISOOUINOLINYLI- BENZAMIDE; INTERMEDIATE 5.1. 8 (1.1 g, 3.25 mmol) was dissolved in 1,2-dichloroethane (70 mL), 4-methyl-imidazole-5-carboxaldehyde (716 mg, 6.5 mmol) was added and the reaction mixture stirred at room temperature for 10 min. Sodium triacetoxyborohydride (2. 1 g, 9.8 mmol) was added and the reaction mixture stirred for a further 16 h. MeOH (5 mL) was added and the reaction mixture concentrated to dryness. The resulting residue was partitioned between EtOAc (50 mL) and NaOH (1N, 30 mL), the aqueous phase washed with EtOAc (2 x 50 mL), dried (MgS04), filtered and concentrated to dryness. The resulting residue was purified by flash chromatography on silica gel (10: 1, DCM: MeOH) to afford COMPOUND 12.1. 21 (736 mg, 54%) as a colourless oil. 1H NMR (500 MHz, CDC) : 8 1. 13,1. 24 (br s, 6H), 2.09 (s), 2.53 (td, J4, 13 Hz, ), 2.76 (br d, J 17 Hz, 1H, ), 2.98 (m, 1H), 3.09 (m, 1H), 3. 28 (br s, 2H), 3.55 (br s, 2H), 3.33 (d, J2 Hz, 1H), 3.60 (d, J2Hz, 1H), 3.76 (s, 3H), 4.56 (s, 1H), 6.58 (s, 1H), 6.64 (br s, 1H), 7.29-7. 30 (m, 5H), 8.30 (s, 1H). 13C NMR (125 MHz, CDC13) : 5 11.2, 13.1, 14.5, 29.2, 39.6, 43.7, 47.0, 49.6, 55.4, 68.0, 112.6, 113.0, 126.5, 127.0, 129.9, 130.0, 130.1, 133.2, 136.1, 136.2, 145.9, 158.1, 171.6. (+) LRESIMS m/z 433 [M+H] +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem