Adding a certain compound to certain chemical reactions, such as: 492-98-8, name is 1H,1’H-2,2′-Biimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 492-98-8, Formula: C6H6N4
General procedure: 2,2′-Biimidazole (0.4 g, 3 mmol) was added to a 100mLthree-necked flask charged with 3-chloropropionic acid (1.3 g,12 mmol), KOH (0.336 g, 6 mmol), and water (10 mL) at roomtemperature. The reaction mixture was adjusted to a pH level of10 to 12 with a 5M aqueous solution of KOH and the reactionmixture was heated slowly to reflux for 8 h. The product mixturewas acidified to pH2-3 with hydrochloric acid (1 M), and thenconcentrated under reduced pressure. The concentrated mixturewas diluted with ethanol and filtered to remove the undissolvedsalt. The final filtrate was concentrated to give a brown viscousliquid (85.1% yield). The product was dried overnight undervacuum before use and analysis.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H,1’H-2,2′-Biimidazole, and friends who are interested can also refer to it.
Reference:
Article; Feng, Miaona; Zhao, Guoying; Gao, Hongling; Zhang, Suojiang; Australian Journal of Chemistry; vol. 68; 10; (2015); p. 1513 – 1517;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem